week 10 Alex
Presentation:
A Brief History of CRISPR-Cas9 Genome-Editing Tools (bitesizebio.com)
CRISPR’d babies: human germline genome editing in the ‘He Jiankui affair’ - PMC (nih.gov)
Background:
-First identified in 1987 by Japanese scientist, Yoshizumi
- A clone of an unusual series of repeated sequences was accidentally made while testing a gene responsible for alkaline phosphatase
He Jiankui:
Scientist that developed the first human babies that had edited genomes
Known for the twins are now resistant to HIV infection due to the DNA editing that he did on their embryo
Edited the DNA in an embryo and implanted it back into a women to then give birth to twins that have the edited DNA
The PROBLEM:
Could have lead to a very poor outcome
CRISPR has still not been tested enough for it to be safe
Was not thinking about the health of the babies or the women that carried the babies
Ended up going to jail
Ethics Principles
-Respect for life and public good
“Engineers shall hold paramount the safety, health, and welfare of the public” -NSPE
Accuracy and Rigour
“Perform services only in areas in which they are competent in”
Integrity and Honest
“Remain honest in all their transactions”
Respect for life and public good
“Shall not aid or abet an unlawful practice of engineering by a person or a firm”
Christian Worldview :
As long as genome editing it used in the proper setting. Such as taking diseased cells and attempting to find a cure for it. Testing such experiments will need to be very carefully established and may only be proceeded with caution
Contemporary Practices :
Impact
-Gave some people the idea that they could also do this experiment, but “better” and perform experiment unsafely again
Impact
- Give some people hope that it can be done and in the future it can be a safe option to cure diseases
Implications
-Leaning from his mistakes in a good way and make CRISPR safe to allow for gene editing
Flow Rates With Graph and equations:
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